Retrospective study of tumors from cattle slaughtered in Lombardy (Italy): preliminary evaluation on the establishment of a bovine cancer registry
DOI:
https://doi.org/10.12834/VetIt.2421.15367.1Keywords:
Abattoirs, Cattle, Comparative oncology, Neoplasms, Registries, Risk factorsAbstract
Forty‑one tumors were detected in a population of 1,649,003 cattle slaughtered in 4 abattoirs in Lombardy over a 5‑year period, for an overall prevalence of 2.5 tumors per 100,000 cattle. Tumors were classified according to the WHO histological classification of tumors of domestic animals. Alimentary and hemopoietic systems were commonly affected with 9 cases each. Other affected sites were the respiratory (n = 3), urinary (n = 2), endocrine (n = 2), musculoskeletal (n = 2), nervous (n = 1), and cardiovascular (n = 1) systems. The peritoneum was affected by 6 cases, while the primary location of 3 tumors of the connective tissues and 3 metastatic carcinomas was unidentified. Liver tumors and mesotheliomas, for which environmental risk factors are well‑known in humans, were common, as well as tumors typically encountered in pediatric human patients (tumors of mesenchymal tissues, pulmonary blastomas and nephroblastomas). These findings suggest the useful role of bovines as sentinel and model for human carcinogenesis. Our study indicates that the establishment of a bovine cancer registry in Lombardy is feasible considering its potential contribution to understanding the role of environmental risk factors in the genesis of tumors in animals and humans.
References
Abbo O., Pinnagoda K., Brouchet L., Leobon B., Savagner F., Oliver I., Galinier P., Castex M.P. & Pasquet M. 2018. Wilms tumor, pleuropulmonary blastoma, and DICER1: case report and literature review. World J Surg Oncol, 16, 164.
Adamesteanu I., Adamesteanu C., Baba I., Danielescu N., Moldovanu N.A. & Rotaru O. 1974. Liver cirrhosis in newborn calves due to diaplacental transmission of aflatoxin. Dtsch Tierarztl Wochenschr, 81, 141.
Alvarez J.E., Rodríguez J.M.M., Pedreira A.S. & Díez A.E. 1982. Casuistica e incidencia tumoral en los animales domesticos. Anales de la Facultad de Veterinaria de León Universidad de Oviedo, 29–37.
Anderson L.J. & Sandison A.T. 1968a. Pulmonary tumours found in a British abattoir survey: primary carcinomas in cattle and secondary neoplasms in cattle, sheep and pigs. Br J Cancer, 22, 47.
Anderson L.J. & Sandison A.T. 1968b. Tumors of the liver in cattle, sheep and pigs. Cancer, 21, 289–301.
Anderson L.J., Sandison A.T. & Jarrett W.F.H. 1969. British abattoir survey of tumours in cattle, sheep and pigs. Vet Rec, 84, 547–551.
Baioni E., Scanziani E., Vincenti M.C., Leschiera M., Bozzetta E., Pezzolato M., Desiato R., Bertolini S., Maurella C. & Ru G. 2017. Estimating canine cancer incidence: findings from a population-based tumour registry in northwestern Italy. BMC Vet Res, 13, 203.
Bastianello S.S. 1982. A survey on neoplasia in domestic species over a 40-year period from 1935 to 1974 in the Republic of South Africa. I. Tumours occurring in cattle. Onderstepoort J Vet Res, 49, 195–204.
Beveridge W.I. & Sobin L.H. 1974. International histological classification of tumours of domestic animals. Introduction. Bull World Health Organ, 50, 137-141.
Brandly P.J. & Migaki G. 1963. Types of tumours found by federal meat inspectors in an eight-year survey. Ann N Y Acad Sci, 108, 872–879.
Brønden L.B., Flagstad A. & Kristensen A.T. 2007. Veterinary cancer registries in companion animal cancer: a review. Vet Comp Oncol, 5, 133–144.
Brønden L.B., Nielsen S.S., Toft N. & Kristensen A.T. 2010. Data from the Danish veterinary cancer registry on the occurrence and distribution of neoplasms in dogs in Denmark. Vet Rec, 166, 586–590.
Bundza A., Dukes T.W. & Stead R.H. 1986. Peripheral nerve sheath neoplasms in Canadian slaughter cattle. Can Vet J, 27, 268.
Carminato A., Bozzato E., Trevisan L., Vascellari M., Catania S., Palma D. de & Mutinelli F. 2008. Blastoma polmonare del bovino. Large Anim Rev, 14, 3–5.
Commission Implementing Regulation (EU) 2019/627 of 15 March 2019 laying down uniform practical arrangements for the performance of official controls on products of animal origin intended for human consumption in accordance with Regulation (EU) 2017/625 of the European Parliament and of the Council and amending Commission Regulation (EC) No 2074/2005 as regards official controls . OJ, L 131, 17.5.2019, 51–100. https://eur-lex.europa.eu/legal-content/en/ALL/?uri=CELEX:32019R0627
Cotchin E. 1960. Tumours of farm animals: A survey of tumours examined at the Royal Veterinary College, London, during 1950-60. Vet Rec, 72, 816–823.
DeNardo P., Bruni B., Paoletti L., Pasetto R. & Sirianni B. 2004. Pulmonary fibre burden in sheep living in the Biancavilla area (Sicily): preliminary results. Sci Total Environ, 325, 51–58.
Dorn C.R., Taylor D.O.N., Frye F.L. & Hibbard H.H. 1968. Survey of animal neoplasms in Alameda and Contra Costa Counties, California. I. Methodology and description of cases. J Natl Cancer Inst, 40, 295–305.
Dragon J., Thompson J., MacPherson M. & Shukla A. 2015. Differential susceptibility of human pleural and peritoneal mesothelial cells to asbestos exposure. J Cell Biochem, 116, 1540–1552.
Dukes T.W., Bundza A. & Corner A.H. 1982. Bovine neoplasms encountered in Canadian slaughterhouses: a summary. Can Vet J, 23, 28.
Grossi A.B., Leifsson P.S., Jensen H.E., Vainer B. & Iburg T. 2013. Histologic and immunohistochemical classification of 41 bovine adrenal gland neoplasms. Vet Pathol, 50, 534–542.
Grüntzig K., Graf R., Hässig M., Welle M., Meier D. & Lott G. 2015. The Swiss Canine Cancer Registry: a retrospective study on the occurrence of tumours in dogs in Switzerland from 1955 to 2008. J Comp Pathol, 152, 161–171.
Hamir A.N., Gusmao L., Hayashi T., Shibamoto T., Bogus E.R. & Gallagher P.A. 1985. An abattoir survey of neoplasms. Aust Vet J, 62, 424–426.
Jensen O.M. & Storm H.H. 1991. Cancer registration: principles and methods. Reporting of results. IARC Sci Publ, 95, 108-125.
Kelley L.C., Puette M., Langheinrich K.A. & King B. 1994. Bovine pulmonary blastomas: histomorphologic description and immunohistochemistry. Vet Pathol, 31, 658–662.
Lucena R.B., Rissi D.R., Kommers G.D., Pierezan F., Oliveira-Filho J.C. & Macêdo J. 2011. A retrospective study of 586 tumours in Brazilian cattle. J Comp Pathol, 145, 20–24.
Manuali E., Morgante R.A., Maresca C., Leonardi L., Purificato I. & Giaimo M.D. 2019. A web-based tumor registration system for a regional Canine Cancer Registry in Umbria, central Italy. Ann Ist Super Sanita, 55, 357–362.
Marosfoi L., Baba A.I. & Cătoi C. 2008. Tumor incidence in slaughtered bovines. Lucr Stiint Stiint Agric a Banat Timisoara, 41, 94–99. https://www.usab-tm.ro/vol8MV/16_vol8.pdf
Merlo D.F., Rossi L., Pellegrino C., Ceppi M., Cardellino U. & Capurro C. 2008. Cancer incidence in pet dogs: findings of the Animal Tumor Registry of Genoa, Italy. J Vet Intern Med, 22, 976–984.
Misdorp W. 1967. Tumours in large domestic animals in the Netherlands. J Comp Pathol, 77, 211-216.
Misdorp W. 1996. Veterinary cancer epidemiology. Vet Q, 18, 32–36.
Monlux A.W., Anderson W.A. & Davis C.L. 1956. A survey of tumors occurring in cattle, sheep, and swine. Am J Vet Res, 17, 646–677.
Munday J.S., Löhr C. V & Kiupel M. 2016. Tumors of the alimentary tract. Tumors Domest Anim, 499–601.
Murray M. 1968. Neoplasms of domestic animals in East Africa. Br Vet J, 124, 514–524.
Naghshineh R., Hagdoost I.S. & Mokhber-Dezfuli M.R. 1991. A retrospective study of the incidence of bovine neoplasms in Iran. J Comp Pathol, 105, 235–239.
Newberne P.M. & Rogers A.E. 1973. Animal model of human disease: primary hepatocellular carcinoma. Am J Pathol, 72, 137.
Parham D. M. 2018. Fibroblastic and myofibroblastic tumors of children: new genetic entities and new ancillary testing. F1000Research, 7, F1000 Faculty Rev-1963.
Plummer P.J.G. 1956. A survey of six hundred and thirty-six tumours from domesticated animals. Can J Comp Med Vet Sci, 20, 239.
Priester W.A. & Mantel N. 1971. Occurrence of tumors in domestic animals. Data from 12 United States and Canadian colleges of veterinary medicine. J Natl Cancer Inst, 47, 1333–1345.
Reisinger R.C. 1963. Epizootiology of spontaneous cancer in cattle with particular reference to malignant lymphoma. Ann N Y Acad Sci, 108, 855–871.
Russell W.O., Wynne E.S., Loquvam G.S. & Mehl D.A. 1956. Studies on bovine ocular squamous carcinoma (“cancer eye”). I. Pathological anatomy and historical review. Cancer, 9, 1–52.
Sastry G.A. & Twiehaus M.J. 1964. A study of the animal neoplasms in Kansas State. Indian Vet J, 41, 317–326.
Shortridge E.H. & Cordes D.O. 1971. Neoplasms in cattle: a survey of 372 neoplasms examined at the Ruakura Veterinary Diagnostic Station. N Z Vet J, 19, 5–11.
Sinnhuber R.O., Hendricks J.D., Wales J.H. & Putnam G.B. 1977. Neoplasms in rainbow trout, a sensitive animal model for environmental carcinogenesis. Ann N Y Acad Sci, 298, 389–408.
Storm H.H., Michelsen E.V., Clemmensen I.H. & Pihl J. 1997. The Danish Cancer Registry-history, content, quality and use. Dan Med Bull, 44, 535–538.
Tedardi M.V., Veneziano D.B., Kimura K.C., Pedra-Mendonça P., Biondi L.R. & Grandi F. 2015. Sao Paulo Animal Cancer Registry, the first in Latin America. Vet Comp Oncol, 13, 154–155.
Thompson J. & Anthony H. 2005. The health effects of waste incinerators. J Nutr Environ Med, 15, 115–156.
Vascellari M., Baioni E., Ru G., Carminato A. & Mutinelli F. 2009. Animal tumour registry of two provinces in northern Italy: incidence of spontaneous tumours in dogs and cats. BMC Vet Res, 5, 39.
Wright B.J. & Conner G.H. 1968. Adrenal neoplasms in slaughtered cattle. Cancer Res, 28, 251–263.
Yamamoto Y., Yamada M., Nakamura K., Takahashi Y. & Miyamoto T. 2006. Nephroblastoma with transcoelomic metastasis in a Japanese black bull. J Vet Med Sci, 68, 891–893.
