Canine trypanosomosis cases: monitor lizard as an unusual vector

Authors

  • Olutoye Adegboye AHS veterinary clinic, Brusubi phase 2, Brususbi Estate, Brusubi, BAC Brusubi, Gambia
  • Olusegun Adegboye AHS veterinary clinic, Brusubi phase 2, Brususbi Estate, Brusubi, BAC Brusubi, Gambia

DOI:

https://doi.org/10.12834/VetIt.3403.22962.2

Keywords:

Canine African trypanosomosis, trypanosome, trypanocide, hemoparasite screening, monitor lizard, oral transmission

Abstract

Trypanosomosis is a well-known sub-Saharan disease. The human form was discovered in The Gambia over 100 years ago. Canine trypanosomosis in The Gambia has never been mentioned in the scientific literature, let alone the involvement of veranus species in its transmission to dogs. The disease's most important vector is the tsetse fly. This fly is abundant in The Gambia, and its infamy for transmitting the disease has been well established. A lot of research efforts have been put into understanding the critical role of this pest in the transmission of the protozoan and the disease in livestock. This report confirms the presence of the disease in domestic dogs in The Gambia, and three canine cases with varied clinical signs, different hematological pictures accompanying the disease, and different effective treatment approaches are reported. Early detection can prevent severe illness and help patients to recover better. This report enhances our understanding on canine trypanosomosis, transmission of the pathogen, and strategies for managing the disease. This report is significant, as it is the first mention of monitor lizards in the transmission of trypanosome parasites to dogs during the fighting between them.

References

Abenga, J. N. (2011). Roles of some factors in the recovery from anemia in pigs experimentally infected with Trypanosoma brucei (PhD Dissertation). Ahmadu Bello University, Zaria, Nigeria.

Abrahamian, F. M., & Goldstein, E. J. (2011). Microbiology of animal bite wound infections. Clinical Microbiology Reviews, 24(2), 231-246. https://doi.org/10.1128/CMR.00041-10

Akpa, P. O., et al. (2007). Comparative efficacy assessment of pentamidine isethionate and diminazene aceturate in the chemotherapy of Trypanosoma brucei brucei infection in dogs. Veterinary Parasitology. https://doi.org/10.1016/J-Vetpar.2007.10.024

Anene, B.M., Kene, R.O.C. and Omamegbe, J.O. (1989). Clinical deafness asosication with relapsing. Trypanosome brucei infection in a dog. A case report, Zaria Veterinary,4:141-144.

Anika, S. M. (1990). Effect of combination of alpha-diffluoromethylornithine and diminazene aceturate in Trypanosoma congolense infection in dogs. Veterinary Parasitology, 37(1), 9-19.

Anosa, V. O. (1988). Hematology and biochemical changes in human/animal trypanosomosis. Part I. Revue d'élevage et de médecine vétérinaire des pays tropicaux, 41(1), 65-78.

Anukwuorji, C & Ossai, Nelson & Emeka, Ubanwa & Edoga, Cyril & Onyekachi, & Chidozie Azubuike, Anukwuorji. (2022). Effect of Dietary Vitamin B 12 on Trypanosoma brucei brucei-Induced Cardiomyopathy of Male Wistar Albino Rats. 10. 526-534.

Aquinos, L. P. C. T. (2000). Importância da infecção por Trypanosoma evansi. http://www.fav.br/programsin/revistas2007/veterinariaimportanciada infecção.pdf

Boyd, B., Colon, L., Doty, J., & Sanders, K. (2021). Beware of the Dragon: A Case Report of a Komodo Dragon Attack. Foot & Ankle Orthopaedics, 6, 247301142110156. https://doi.org/10.1177/24730114211015623

Ciccarelli, A. B., Frank, F. M., Puente, V., Malchiodi, E. L., Batlle, A., & Lombardo, M. E. (2012). Antiparasitic Effect of Vitamin B12 on Trypanosoma cruzi. Antimicrobial Agents and Chemotherapy, 56(10), 5315-5320. https://doi.org/10.1128/AAC.00481-12

CVBD, (2010).Canine Vector Born Diseases. Trypanosomosis. 4th Internal Symposium.

Desquenes, M. (2004). Livestock trypanosomes and their vectors in Latin America (CIRAD-EMVT Publication, OIE, Paris, ISBN 92-9004-634-X, 174).

Edoga, Cyril & Chidozie Azubuike, Anukwuorji & E., Ejo & E., Ani. (2020). Antioxidant Effects of Mixed Doses of Vitamins B 12 and E on Male Wistar Albino Rats Infected with Trypanosoma Brucei Brucei. Immunology and Infectious Diseases. 8. 7-13. 10.13189/iid.2020.080201.

Eloy, L. J., & Lucheis, S. B. (2009). Canine trypanosomosis: etiology of infection and implication for public health. Journal of Venomous Animals and Toxins Including Tropical Diseases, 15(4), 589-611.

Emeribe, A & Anosa, V. (1989). Haematology of experimental gambiense trypanosomiasis, I. Platelet and other haemostatic changes. The Central African journal of medicine. 34. 286-90.

Emeribe, A. O., & Anosa, V. O. (1991). Hematology of experimental T. gambiense infection. 2 Erythrocytes and leucocytes changes. Revue D’elevage et du Medicine Veterinaire des pays Tropicaux, 44, 53-57.

Forde, R. M. (1902). Some clinical notes on a European patient in whose blood a trypanosome was observed. Journal of Tropical Medicine, 5, 261-263.

Greene, C. E. (2006). Trypanosomosis: infectious diseases of dog and cat (3rd ed.). W. B. Sanders.

Igbokwe, I., & Anosa, V. O. (1989). Response to anemia in experimental Trypanosoma vivax infection of sheep. Journal of Comparative Pathology, 100, 111-116.

Jones, T. C., et al. (2000). Molestias causadas por protozoiarios. In: T. C. Jones, D. Hunt, & N. W. King (Eds.), Patologia Veterinaria, 6th ed. (pp. 559-610). Sao Paulo: Manote.

Koludarov, I., Jackson, T. N., Brouw, B. O. D., Dobson, J., Dashevsky, D., Arbuckle, K., ... Fry, B. G. (2017). Enter the Dragon: The Dynamic and Multifunctional Evolution of Anguimorpha Lizard Venoms. Toxins (Basel), 9(8), 242. https://doi.org/10.1016/j.toxicon.2020.11.013

Maraghi, S., et al. (1995). Oral transmission of trypanosomes of the subgenus Herpetosoma from small mammals. Parasitology Research, 77(8-9), 693-695. https://doi.org/10.1007/BF00931848

Mbaya, A., Kumshe, H., & Nwosu, C. (2012). The Mechanisms of Anaemia in Trypanosomosis: A Review. https://doi.org/10.5772/29530

Mebs, D., Lomonte, B., Fernández, J., Calvete, J. J., Sanz, L., Mahlow, K., ... Fry, B. G. (2021). The earless monitor lizard Lanthanotus borneensis - A venomous animal? Toxicon, 189, 73-78. https://doi.org/10.1016/j.toxicon.2020.11.013

Miller, J. B. (2005). Hyperthermia and fever of unknown origin. In: S. J. Ettinger & E. C. Feldman (Eds.), Textbook of Veterinary Internal Medicine, Vol 1, 6th ed. (pp. 9-13). St. Louis: Elsevier Sanders.

Moloo S. K., Losos G. J. & Kutuza S. B. (1973) Transmission of Trypanosoma brucei to cats and dogs by feeding on infected goats, Annals of Tropical Medicine & Parasitology, 67:3, 331-334, DOI: 10.1080/00034983.1973.11686894

Murray, P. K., & Jennings, F. W. (1983). African trypanosomosis: chemotherapy in rodent models of sleeping sickness. In: G. Keush & T. Wadstrom (Eds.), Animal Models for Experimental Bacterial and Parasitic Infections (pp. 343-354). Elsevier.

Naesssens, J., et al. (2005). TNF-alpha mediates the development of anemia in a murine Trypanosoma brucei rhodesiense infection, but not anemia associated with a murine Trypanosoma congolense infection. Clinical and Experimental Immunology, 139(3), 495-510.

Njagu, Z., et al. (1999). Isolation of Trypanosoma brucei from the monitor lizard (Varanus niloticus) in an endemic focus of Rhodesian sleeping sickness in Kenya. Acta Tropica, 72(2), 137-148. https://doi.org/10.1016/S0001-706X(98)00092-3

Njagu, Z., Mihok, S., Kokwaro, E., & Verloo, D. (1999). Isolation of Trypanosoma brucei from the monitor lizard (Varanus niloticus) in an endemic focus of Rhodesian sleeping sickness in Kenya. Acta Tropica, 72(2), 137-148. https://doi.org/10.1016/S0001-706X(98)00092-8

Nwoha, R. O., & Anene, B. N. (2011a). Clinical signs and pathological changes in dogs with single and conjunct experimental infections of Trypanosoma brucei brucei and Ancylostoma Caninum. Journal of Veterinary Parasitology, 24(2), 91-102.

Nwoha, R. O., et al. (2013). Serum biochemical and liver enzymes changes in dogs with single and conjunct experimental infections of T. brucei and Ancylostoma caninum. African Journal of Biotechnology, 12(6), 618-624.

Nwoha, R.I.O. and Anene, B.M. (2011b). Changes in packed cell volume and haemoglobin concentration in dogs with single and conjunct experimental infections of T. brucei and A. caninum. Ohillip. Journal of Animal Science,37(2):151-158

Obi, C. F., et al. (2022). Drug-resistant trypanosome isolates populations in dogs in Enugu North Senatorial Zone, Southeastern Nigeria. Parasitology Research, 121(1), 423-431. https://doi.org/10.1007/s00436-021-07362-x

OIE (2008).Trypanosomosis. OIE Terrestial Manual.Chapter 4, 18

OIE terrestrial manual 2018

Pawlukianiec, C., et al. (2020). A New Insight into Meloxicam: Assessment of Antioxidant and Anti-Glycating Activity in In Vitro Studies. Pharmaceuticals (Basel), 13(9), 240. https://doi.org/10.3390/ph13090240

Raina AK, Kumar R, Rajora VS, Sridhar, Singh RP. Oral transmission of Trypanosoma evansi infection in dogs and mice. Vet Parasitol. 1985 Jun;18(1):67-9. doi: 10.1016/0304-4017(85)90009-3. PMID: 4049728.

Rashid, I., et al. (2014). Use of Cymelarsan® and manganese chloride for treatment of the canine Trypanosomiasis (Surra): a research report. Advances in Animal and Veterinary Sciences, 2, 104-105.

Rawlings, P., et al. (1993). The distribution of the tsetse flies Glossina morsitans submorsitans and G. palpalis gambiensis (Diptera: Glossinidae) in The Gambia and the application of survey results to tsetse and trypanosomiasis control. Bulletin of Entomological Research, 83(4), 625-632. https://doi.org/10.1017/S0007485300040050

Sangeetha, S. G., et al. (2022). Oral transmission of Trypanosoma evansi infection in a German Shepherd dog—a rare case report. Comparative Clinical Pathology, 31(1), 175-179. https://doi.org/10.1007/s00580-022-03324-6

Shugaba, A., et al. (1994). Differences (O Acetyl and Glycoyl groupus) in erythrocyte surface sialic acids of trypanotolerant N’dama and trypanosusceptible Zebu cattle. Journal of Comparative Pathology, 110, 91-95.

Sivajothi, S., et al. (2015). Hematological & biochemical changes in experimental Trypanosoma evansi infection in rabbits. Journal of Parasitic Diseases, 39(2), 216-220. https://doi.org/10.1007/s12639-013-0321-6

Sophie, R., et al. (2015). A study on African animal trypanosomosis in four areas of Senegal. Folia Parasitologica.

Sweet, S. (2016). Chasing Flamingos: Toxicofera and the Misinterpretation of Venom in Varanid Lizards.

Tehrani, H., Tejero-Trujeque, R., & Dhital, S. K. (2008). Re: Septic arthritis due to a Savannah Monitor lizard bite: A case report. Journal of Hand Surgery (European Volume), 33(6), 810. https://doi.org/10.1177/1753193408092495

Uilenberg, G. (1998). A field guide for the diagnosis, treatment, and prevention of African animals. Chapter 1: African animal trypanosomes. FAO Corporate Repository.

Verones, R., & Focaccia, R. (2002). Tratado de Infectología (2nd ed.). Atheneu.

Vikrant, S., & Verma, B. S. (2014). Monitor lizard bite-induced acute kidney injury--a case report. Renal Failure, 36(3), 444-446. https://doi.org/10.3109/0886022X.2013.868223.

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Published

2024-07-31

How to Cite

Adegboye, O., & Adegboye, O. (2024). Canine trypanosomosis cases: monitor lizard as an unusual vector. Veterinaria Italiana, 60(2). https://doi.org/10.12834/VetIt.3403.22962.2

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Case report

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