Canine brucellosis due to Brucella canis: description of the disease and control measures
DOI:
https://doi.org/10.12834/VetIt.2561.16874.1Keywords:
Brucellosis, Brucella canis, Dog, ZoonosisAbstract
Brucellosis is a contagious disease caused by bacteria of the genus Brucella, which can affect different animal species. Dogs may occasionally be infected with B. abortus, B. melitensis or B. suis, or by the endemic form of the disease, caused by B. canis. Among the brucellosis‑affecting domestic animals, that of the dog is certainly the least frequent, but also the least studied. Canine brucellosis due to B. canis represents the dog‑specific brucellosis, both because it is the main susceptible animal species, and because it constitutes its fundamental reservoir of infection. The disease can also affect humans, although its course does not assume the characteristics of severity typical of the infection determined by the ‘classical’ species of the genus Brucella. In Italy, there are frequent imports of dogs from countries where the disease is present, often with non‑controlled movements and without sanitary controls. Considering that the zoonotic potential of the disease can be favored by the close cohabitation between man and dog, which occurs especially in urban environments, canine brucellosis has to be regarded as a public health problem susceptible to introduction and spread in the Italian territory.
References
Alton G.G., Jones L.M. & Pietz D.E. 1975. Laboratory techniques in brucellosis. 2nd Ed. World Health Organization, Geneva, Switzerland.
Alton G.G., Jones L.M., Angus R.D. & Verger J.M. 1988. Techniques for the brucellosis laboratory. I.N.R.A., Paris, 169-174.
Badakhsh F.F., Carmichael L.E. & Douglas J.A. 1982. Improved rapid slide agglutination test for presumptive diagnosis of canine brucellosis. J Clin Microbiol, 15 (2), 286-289.
Baldi P.C., Wanke M.M., Loza M.E., Monachesi N. & Fossati C.A. 1997. Diagnosis of canine brucellosis by detection of serum antibodies against an 18 kDa cytoplasmic protein of Brucella spp. Vet Microbiol, 57, 273–281.
Berthelot X. & Garin-Bastuji B. 1993. Brucelloses canines. Point Vétérinaire, 25(152), 125-129.
Brower A., Okwumabua O., Massengill C., Muenks Q., Vanderloo P., Duster M., Homb K. & Kurth K. 2007. Investigation of the spread of Brucella canis via the U. S. interstate dog trade. Int J Infect Dis, 11, 454–458. doi: 10.1016/j.ijid.2006.12.009
Boeri E.J., Wanke M.M., Madariaga M.J., Teijeiro M.L., Elena S.A. & Trangoni M.D. 2018. Comparison of four polymerase chain reaction assays for the detection of Brucella spp. in clinical samples from dogs. Vet World, 11, 201-208. http://dx.doi.org/10.14202/vetworld.2018.201-208
Brown J., Blue J.L., Wooley R.E. & Dreesen D.W. 1976. Brucella canis infectivity rates in stray and pet dog populations. Am J Public Health, 66, 889–891. http://dx.doi.org/10.2105/AJPH.66.9.889
Buonavoglia D., Malena G., Mosca R., Benchetti G., Narcisi D. & Corsalini T. 1992: Ricerca di anticorpi per Brucella canis in sieri di cane. Atti SISVet, XLIV, 1097-1101.
Carmichael L.E. 1990. Brucella canis. In Animal Brucellosis (Nielsen K. & Duncan J. R., Eds). CRC Press, Boca Raton, Florida, 335-350.
Carmichael L. E. & Bruner D. W. 1968. Characteristics of a newly-recognized species of Brucella responsible for infectious canine abortions. Cornell Vet, 58, 579-592.
Carmichael L. E. & Joubert J. C. 1988. Transmission of Brucella canis by contact exposure. Cornell Vet, 78, 63-73.
Carmichael L. E. & Kenney R.M. 1968. Canine abortion caused by Brucella canis. J Am Vet Med Assoc, 152, 605–616.
Carmichael L.E. & Shin S. J. 1996. Canine brucellosis: a diagnostician’s dilemma. Semin Vet Med Surg (Small Anim), 11, 161–165.
Carmichael L.E Zoha S.J. & Flores-Castro R. 1984. Problems in the serodiagnosis of canine brucellosis: dog responses to cell wall and internal antigens of Brucella canis. Dev Biol Stand, 56, 371-383.
Carmichael L.E. 2012. Canine brucellosis. In Infectious diseases of the dog and cat (Greene C.E., ed.) 4th Ed. London, Elsevier Health Sciences, 398–411.
Carmichael L.E. & Bruner D.W. 1968. Characteristics of a newly recognized species of Brucella responsible for infectious canine abortion. Cornell Vet , 58, 579–592.
Carmichael L.E. & Greene C.E. 2006. Canine brucellosis. In Infectious Diseases of the Dog and Cat (Greene C.E., ed.). 3rd ed. Philadelphia, Pennsylvania, Elsevier Saunders, 369–381.
Casalinuovo F., Cacia A., Lopresti A., Miceli M. E., Viterbo A. & Fenizia D. 1996. La brucellosi in Calabria. Ricerca delle fonti di contagio. Vet Ital, 32(20), 23-28.
Castrillón-Salazar L., Giraldo-Echeverri C.A., Sánchez-Jiménez M.M. & Olivera-Angel M. 2013. Factors associated with Brucella canis seropositivity in kennels of two regions of Antioquia, Colombia. Cad Saude Publica, 29, 1955 1973. http://dx.doi.org/10.1590/0102-311X00133013
Center for Disease Control (CDC). 1977. Brucellosis surveillance. Annual summary 1977.CDC, Atlanta.
Center for Food Security and Public Health (CFSPH).2018. The Canine Brucellosis: Brucella canis . Ames, Iowa. http://www.cfsph.iastate.edu/Factsheets/pdfs/brucellosis_canis.pdf
Ciuchini F., Sala V., Pistoia C., Piccininno G., Pievaroli A. & Fantini C. 1982. Brucellosi da Brucella canis: rilievi anticorpali su cani della città e del suburbio di Roma. Clinica Veterinaria, 105 (3), 138-144.
Colella G., Corsalini T. & Goffredo G. 1980. Indagine sierologica sulla brucellosi del cane in Puglia e Basilicata. Atti SISVet, 34, 330-332.
Corbel, M. J. & Brinkley-Morgan W. J. 1989. Genus Brucella. In Bergey's Manual of Systematic Bacteriology, vol. 1, (Kreig N. R. & Holt S. D., Ed.) Williams & Wilkins, Baltimora, 377-388.
Corrente M., Franchini D., Decaro N., Greco G., D’Abramo M., Greco M.F., Latronico F., Crovace A. & Martella V. 2010. Detection of Brucella canis in a dog in Italy. New Microbiologica , 33, 337-341.
Cosford K.L. 2018. Brucella canis: An update on research and clinical management. Can Vet J, 59, 74–81.
Dentinger C.M., Jacob K., Lee L.V., Mendez H.A., Chotikanatis K., McDonough P.L., Chico D.M., De B.K., Tiller R.V., Traxler R.M., Campagnolo E.R., Schmitt D., Guerra M.A. & Slavinski S.A. 2015. Human Brucella canis infection and subsequent laboratory exposures associated with a puppy, New York City, 2012. Zoonoses Public Health, 62, 407–414. http://dx.doi.org/10.1111/zph.12163
Feldman E. C. & Nelson R. W. 1996. Brucellosi. In Endocrinologia e riproduzione del cane e del gatto. UTET, Torino, 731-739.
Flores-Castro R. & Carmichael L.E. 1977. Canine brucellosis: current status of methods for diagnosis and treatment. 27th Gaines Veterinary Symposium, 17–24.
Flores- Castro R. & Carmichael L. E. 1981. Brucella canis infection in dogs. Rev Latinoamericana Microbiologia, 23, 75.
Flores-Castro R. & Segura R. 1976. A serological and bacteriological survey of canine brucellosis in Mexico. Cornell Vet, 66, 347–352.
Fredrickson L.E. & Barton C.E. 1974. A serologic survey for canine brucellosis in a metropolitan area. J Am Vet Med Assoc, 165, 987–989.
Georgia Department of Agriculture (GDA). 2020. Canine Brucellosis (Brucella canis). Atlanta, Georgia. http://agr.georgia.gov/Data/Sites/1/media/ag_animalindustry/animal_health/files/caninebrucellosis.pdf
George L. W. & Carmichael L. E. 1974. A plate agglutination test for the rapid diagnosis of canine brucellosis. Am J Vet Res, 35 (7), 905-909.
George L. W., Duncan J. R. & Carmichael L. E. 1979. Semen examination in dogs with canine brucellosis. Am J Vet Res, 40 (11), 1589-1595.
Gyuranecz M., Szeredi L., Rónai Z., Dénes B., Dencso L., Dán Á., Pálmai N., Hauser Z., Lami E., Makrai L., Erdélyi K. & Jánosi S. 2011. Detection of Brucella canis-induced reproductive diseases in a kennel. J Vet Diagn Invest, 23, 143–147. http://dx.doi.org/10.1177/104063871102300127
Henderson R. A., Horlein B. F., Kramer T. & Meyer M. E. 1974. Discospondylitis in three dogs infected with Brucella canis. J Am Vet Med Ass, 165 (5), 451-455.
Hensel M.E., Negron M. & Arenas-Gamboa A.M. 2018. Brucellosis in Dogs and Public Health Risk. Emerg Infect Dis, 24, 8, 1401-1406.
Hollett R.B. 2006. Canine brucellosis: Outbreaks and compliance. Theriogenology, 663, 575–587.
Hurov L., Troy G. & Turnwald G. 1978. Diskospondylitis in the dog: 27 cases. J Am Vet Med Assoc, 173, 275–281.
Kaden R., Ågren J., Båverud V., Hallgren G., Ferrari S., Börjesson J., Lindberg M., Bäckman S. & Wahabbg T. 2014. Brucellosis outbreak in a Swedish kennel in 2013: determination of genetic markers for source tracing. Vet Microbiol, 174, 523 - 530. http://dx.doi.org/10.1016/j.vetmic.2014.10.015
Kang S.I., Lee S.E., Kim J.Y., Lee K., Kim J.W., Lee H.K., Sung S.R., Heo Y.R., Jung S.C. & Her M. 2014. A new Brucella canis species-specific PCR assay for the diagnosis of canine brucellosis. Comp Immunol Microbiol Infect Dis, 37, 237–241. http://dx.doi.org/10.1016/j.cimid.2014.07.003
Kauffman L.K., Bjork J.K., Gallup J.M., Boggiatto P.M., Bellaire B.H. & Petersen C.A. 2014. Early detection of Brucella canis via quantitative polymerase chain reaction analysis. Zoonoses Public Health, 61, 48–54. http://dx.doi.org/10.1111/zph.12041
Keid L.B., Soares R.M., Vasconcellos S.A., Megid J., Salgado V.R. & Richtzenhain L.J. 2009. Comparison of agar gel immunodiffusion test, rapid slide agglutination test, microbiological culture, and PCR for the diagnosis of canine brucellosis. Res Vet Sci, 86, 22–26.
Keid L.B., Soares R.M., Vieira N.R. Megid J., Salgado V.R., Vasconcellos S.A.,da Costa M., Gregori F. & Richtzenhain L.J. 2007. Diagnosis of canine brucellosis: comparison between serological and microbiological tests and a PCR based on primers to 16S-23S rDNA interspacer. Vet Res Commun, 31, 951–965. http://dx.doi.org/10.1007/s11259-006-0109-6
Keid L.B., Soares R.M., Vasconcellos S.A., Megid J., Salgado V.R., Megid J. & Richtzenhain L.J. 2010. Comparison of a PCR assay in whole blood and serum specimens for canine brucellosis diagnosis. Vet Rec , 167, 96-99. http://dx.doi.org/10.1136/vr.c3811
Kerwin S.C., Lewis D.D., Hribernik T.N., Partington B., Hosgood G. & Eilts B.E. 1992. Diskospondylitis associated with Brucella canis infection in dogs: 14 cases (1980–1991). J Am Vet Med Assoc, 201, 1253–1257.
Kornegay J. N. 1983. Discospondylitis. In Current Veterinary Therapy (Kirk R. W., Ed.). WB Saunders Co., Philadelphia, 718-721.
Krueger W.S., Lucero N.E., Brower A., Heil G.L. & Gray G.C. 2014. Evidence for unapparent Brucella canis infections among adults with occupational exposure to dogs. Zoonoses Public Health, 61, 509–518. http://dx.doi.org/10.1111/zph.12102
Lawaczeck E., Toporek J., Cwikla J. & Mathison B.A. 2011. Brucella canis in a HIV-infected patient. Zoonoses Public Health, 58, 150–152. http://dx.doi.org/10.1111/j.1863-2378.2010.01334.x
López-Goñi I., García-Yoldi D., Marín C.M., de Miguel M.J., Barquero-Calvo E., Guzmán-Verri C., Albert D. & Garin-Bastuji B. 2011. New Bruce-ladder multiplex PCR assay for the biovar typing of Brucella suis and the discrimination of Brucella suis and Brucella canis. Vet Microbiol , 154, 152–155.
Lucero N.E., Corazza R., Almuzara M.N., Reynes E., Escobar G.I., Boeri E. & Ayala S.M. 2010. Human Brucella canis outbreak linked to infection in dogs. Epidemiol Infect, 138, 280–285. http://dx.doi.org/10.1017/S0950268809990525
Lucero N.E., Escobar G.I., Ayala S.M. & Jacob N. 2005. Diagnosis of human brucellosis caused by Brucella canis. J Med Microbiol, 54, 457–461. http://dx.doi.org/10.1099/jmm.0.45927-0
Marzetti S., Carranza C., Roncallo M., Escobar G.I. & Lucero N.E. 2013. Recent trends in human Brucella canis infection. Comp Immunol Microbiol Infect Dis, 36, 55–61. http://dx.doi.org/10.1016/j.cimid.2012.09.002
Mateau de Antonio E.M., Martin M. & Soler M. 1993. Use of indirect enzyme-linked immunosorbent assay with hot saline solution extracts of a variant (M−) strain of Brucella canis for diagnosis of brucellosis in dogs. Am J Vet Res, 54, 1043–1046.
Mol J.P.S., Guedes A.C.B., Eckstein C., Quintal A.P.N., Souza T.D., Mathias L.A., Haddad J.P.A., Paixão T.A. & Santos R.L. 2020. Diagnosis of canine brucellosis: comparison of various serologic tests and PCR. J Vet Diagn Invest, 32, 77–86. https://doi.org/10.1177/10406387198910
Moore J.A. 1969. Brucella canis infection in dogs. J Am Vet Med Assoc, 155, 2034–2037.
Moreno S., Ariza J., Espinosa F.J., Podzamczer D., Miró J.M., Rivero A., Rodríguez-Zapata M., Arrizabalaga J., Mateos R. & Herrero F. 1998. Brucellosis in patients infected with the human immunodeficiency virus. Eur J Clin Microbiol Infect Dis, 17, 319–326. http://dx.doi.org/10.1007/BF01709454
Munford R.S., Weaver R.E., Patton C., Feeley J.C. & Feldman R.A. 1975. Human disease caused by Brucella canis. A clinical and epidemiologic study of two cases. JAMA, 231, 1267–1269. http://dx.doi.org/10.1001/jama.1975.03240240037023
National Association of State Public Health Veterinarians (NASPHV). 2012. Public Health Implications of Brucella canis Infections in Humans.
http://www.nasphv.org/Documents/BrucellaCanisInHumans.pdf
Nicoletti P.1991. Further studies on the use of antibiotics in canine brucellosis. Compend Contin Educ Pract Vet, 13 (6), 944-947.
Nicoletti P. & Chase A. 1987a. The use of antibiotics to control canine brucellosis. Compend Contin Educ Pract Vet, 9 (11), 1063-1066.
Nicoletti P. & Chase A. 1987b. An evaluation of methods to diagnose B. canis in dogs. Compend Contin Educ Pract Vet, 9 (11), 1071-1074.
Pollock R.V.H. 1979. Canine brucellosis: current status. Compend Contin Educ Pract Vet, 1, 255–267.
Prosperi S., Ostanello F., Baldelli R. & Falcone A. 1994. Ruolo del cane nella epidemiologia della Brucellosi ovi-caprina. Vet Ital, 30 (12), 2-6.
Reike J. A. & Rhodes H.E. 1975. Brucella canis isolated from the eye of a dog. J Am Vet Med Ass, 165, 1734.
Rhoades H.E. & Mesfin G.M. 1980. Brucella canis infection in a kennel. Vet Med Small Anim Clin ,75, 595–599.
Rumley R.L. & Chapman S.W. 1986. Brucella canis: an infectious cause of prolonged fever of undetermined origin. South Med J, 79, 626–628. http://dx.doi.org/10.1097/00007611-198605000-00027
Saegusa J., Ueda K., Goto Y. & Fujiwara K. 1978. Ocular lesions in experimental canine brucellosis. Jap J Vet Sci, 39, 181-185.
Serikawa T. & Muraguchi T. 1979. Significance of urine in transmission of canine brucellosis. Jap J Vet Sci, 41, 607-616.
Smeak D. D., Olmstead M. L. & Horn R. B. 1987. Brucella canis osteomyelitis in two dogs with total hip replacement. J Am Vet Med Ass, 191 (8), 986-990.
Swenson R.M., Carmichael L.E. & Cundy K.R. 1972. Human infection with Brucella canis. Ann Intern Med, 76, 435–438. http://dx.doi.org/ 10.7326/0003-4819-76-3-435
Tolari F. & Pizzirani S. 1978. Indagini preliminari sulla esistenza della brucellosi canina da Brucella canis in Italia. Annali Facoltà Medicina Veterinaria Pisa, 31, 107-113.
Tosi M.F. & Nelson T.J. 1982. Brucella canis infection in a 17-month-old child successfully treated with moxalactam. J Pediatr, 101, 725–727. http://dx.doi.org/10.1016/S0022-3476(82)80301-6
United States Department of Agriculture Animal and Plant Health Inspection Service (USDA). 2015. Best Practices for Brucella canis Prevention and Control in Dog Breeding Facilities. https://www.aphis.usda.gov/animal_welfare/downloads/Brucella_canis_prevention.pdf
Valente C., Gialletti L., Capua I. & Antognoni M. T. 1991. Brucellosi del cane. Indagine sierologica e batteriologica per Brucella canis. Archivio Veterinario Italiano, 42, 3, 135-139.
Vesco G., Caracappa V. & Guercio V. 1987. Indagine sierologica nei confronti di B. canis in cani di affezione nella Sicilia occidentale. Giornale di Malattie Infettive e Parassitarie, 39 (5), 450-451.
Wallach J.C., Giambartolomei G.H., Baldi P.C. & Fossati C.A. 2004. Human infection with M- strain of Brucella canis. Emerg Infect Dis, 10, 146–148. http://dx.doi.org/10.3201/eid1001.020622
Wanke M.M. 2004. Canine brucellosis. Animal Reprod Sci, 82–83, 195–207.
Weber A. & Krauss H. 1977. Zum serologischen Nachweis von Brucella canis-Infektionen bei Hunden mittels Komplementbindungsreaktion. Zentralbl Veterinarmed B, 24, 746–752.
Yagupsky P. & Baron E.J. 2005. Laboratory exposures to Brucellae and implications for bioterrorism. Emerg Infect Dis, 11, 1180–1185. http://dx.doi.org/10.3201/eid1108.041197
Yu W.L. & Nielsen K. 2010. Review of detection of Brucella spp. by polymerase chain reaction. Croat Med J, 51, 306–313.
Zoha S.J. & Carmichael L. E. 1982. Serological responses of dogs to cell wall and internal antigens of B. canis. Vet Microbiol, 28, 1-4.
Zoha S.J. & Walsh R. 1982. Effect of a two-stage antibiotic regimen in dogs naturally infected with Brucella canis. J Am Vet Med Ass, 180, 1474.
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