Renal carcinoma with metastatic spread in a tiger (Panthera tigris): morphological and immunohistochemical study


renal cell carcinoma

How to Cite

Maniscalco, L., Acutis, P. L. ., Biolatti, C., Laguardia, D. R., Di Blasio, A., Dondo, A., Bozzetta, E., & Varello, K. (2022). Renal carcinoma with metastatic spread in a tiger (Panthera tigris): morphological and immunohistochemical study. Veterinaria Italiana, 58(4). https://doi.org/10.12834/VetIt.2475.16553.2


A 12‑year‑old intact male Panthera tigris presented with pain and weight loss was euthanatized. Necroscopical examination revealed a neoplastic mass expanding to the left renal pelvis with metastatic dissemination to local lymph node, adrenal gland, and lung. Immunohistochemical characterization was performed revealing co‑expression of both cytokeratin and vimentin and negativity for both PAX8 and c‑KIT. Considering histochemical and immunohistochemical results the tumour was classified as renal cell carcinoma with metastatic spread. This report provides insights into the morphological and immunohistochemical features of renal cell carcinoma in Panthera tigris.



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Copyright (c) 2023 Lorella Maniscalco, Pier Luigi Acutis, Cristina Biolatti, Daniele R Laguardia, Alessia Di Blasio, Alessandro Dondo, Elena Bozzetta, Katia Varello